Publikationen

Quality of Life after Rhinoplasty: A Prospective Study.

Papadopulos NA, Liebmann J, Kloeppel M, Heinrich G, Machens HG, Staudenmaier R., Niehaus R.
Facial Plast Surg. 2021 Oct;37(5):639-645. doi: 10.1055/s-0041-1725174. Epub 2021 Mar 11.
PMID: 33706388

Development of volume-stable adipose tissue constructs using polycaprolactone-based polyurethane scaffolds and fibrin hydrogels.

Adipose tissue engineering aims at the restoration of soft tissue defects and the correction of contour deformities. It is therefore crucial to provide functional adipose tissue implants with appropriate volume stability.

Prefabrication and free transfer of a tissue engineered composite flap - An experimental model in the rat.

Mandlik V., Kehrer A., Jiga L., Hoinoiu B., Ionac M., Jung F., Staudenmaier R., Prantl L.
Clin Hemorheol Microcirc. 2016;64(3):319-331. doi: 10.3233/CH-168120.
PMID: 27935552

The technique of flap-prefabrication has been successfully established in tissue engineering: missing intrinsic vascularisation of engineered tissue can be generated in vivo by microsurgical vesselloop construction. It is possible to move engineered tissue into a defect with microsurgery.

Management and prevention of acute bleedings in the head and neck area with interventional radiology.

Storck K, Kreiser K, Hauber J, Buchberger AM, Staudemaier R, Kreutzer K, Bas M.
Head Face Med. 2016 Jan 23;12:6. doi: 10.1186/s13005-016-0103-3.
PMID: 26803587 Free PMC article.

The Interventional Neuroradiology is becoming more important in the interdisciplinary treatment of acute haemorrhages due to vascular erosion and vascular tumors in the head and neck area.

The Psychologic and Psychosocial Impact of Otoplasty on Children and Adults.

Papadopulos NA, Niehaus R, Keller E, Henrich G, Papadopoulos ON, Staudenmaier R, Kovacs L, Peter Herschbach, Pototschnig H, Machens HG.
J Craniofac Surg. 2015 Nov;26(8):2309-14. doi: 10.1097/SCS.0000000000001990.
PMID: 26491919

In previous studies, our research group already evaluated the impact of aesthetic surgery on "quality of life" (QoL). This study evaluates QoL factors and perceptions of well-being after otoplasty as a single indication.

Vascularization of engineered cartilage constructs in a mouse model.

Tissue engineering of cartilage tissue offers a promising method for reconstructing ear, nose, larynx and trachea defects. However, a lack of sufficient nutrient supply to cartilage constructs limits this procedure.

Total reconstruction of the auricle: our experiences on indications and recent techniques.

Auricular reconstruction is a great challenge in facial plastic surgery. With the advances in surgical techniques and biotechnology, different options are available for consideration.

Complications in 312 cases of nasal and auricular reconstruction via autologous rib cartilage.

We present the results and complications with autologous rib cartilage in comparison to other materials in nasal and auricular reconstruction using a large patient collective from our clinic.

Prefabrication of 3D cartilage contructs: towards a tissue engineered auricle--a model tested in rabbits.

The reconstruction of an auricle for congenital deformity or following trauma remains one of the greatest challenges in reconstructive surgery. Tissue-engineered (TE) three-dimensional (3D) cartilage constructs have proven to be a promising option, but problems remain with regard to cell vitality in large cell constructs.

Influence of different growth factors on chondrogenic differentiation of adipose-derived stem cells in polyurethane-fibrin composites.

Chondrogenic differentiation of adipose-derived stem cells (ASCs) has proven to be feasible. To compensate for laryngeal palsy or cartilage defects after surgery or trauma using tissue engineering, a formable and stable scaffold material is mandatory.

Management and prognosis of patients with squamous cell carcinomas of the nasal cavity and the paranasal sinuses

Squamous cell carcinomas (SCC) of the nasal cavity and the paranasal sinuses are a very rare and poorly understood tumor entity. To date, no consistent management strategy exists.

Chondrocytes suspended in modified fibrin glue for vocal fold augmentation: An in vitro study in a porcine larynx model.

Injection laryngoplasty is an option for treatment of dysphonia following vocal fold paralysis. Modified fibrin glue with suspended chondrocytes might be a favorable cell-based material for permanent vocal fold medialization.

Engineering of vascularized adipose constructs.

Adipose tissue engineering offers a promising alternative to the current surgical techniques for the treatment of soft tissue defects. It is a challenge to find the appropriate scaffold that not only represents a suitable environment for cells but also allows fabrication of customized tissue constructs, particularly in breast surgery.

Grisel's syndrome after otoplasty

Grisel's syndrome is known as a very rare complication of ENT surgery. It is described as non-traumatic atlantoaxial rotatory subluxation, often seen after tonsillectomy or adenoidectomy in children.

Neovascularisation and free microsurgical transfer of cartilage-engineered constructs

Clinical imperatives for new cartilage to replace or restore the function of traumatized or missing tissue as a consequence of trauma, inherent malformations or disease has led to the need for therapies or procedures to generate cartilage for clinical applications.

Reconstruction of the auricle. Preface.

Reconstruction of the auricle. Preface.

Optimization of fibrinogen isolation for manufacturing autologous fibrin glue for use as scaffold in tissue engineering.

Numerous manufacturing techniques for autogenous fibrin glue used as scaffold material have been described. As there is no consensus regarding the influence of chemical additives on cell biology.

Combined aesthetic and functional reconstruction of ear malformations.

urgery for major malformations of the outer and middle ear involves aesthetic as well as functional aspects.

Customized tissue engineering for ear reconstruction.

Tissue engineering (TE) of cartilage for reconstructive surgery has proven to be a promising option for obtaining tissue for 3D structures that results in minimal donor site morbidity.

Treatment of infection of the ankle joint after subtotal talectomy using the free gracilis muscle: a case report from Hanoi, Vietnam.

Treatment of infection of the ankle joint after subtotal talectomy using the free gracilis muscle: a case report from Hanoi, Vietnam.

Microsurgical thumb replantation following traumatic amputation: preliminary results in Hanoi, Vietnam

Replantation using microsurgical techniques is a fairly new procedure in Vietnam. We reviewed and evaluated our 7-year results of thumb replantation in Vietnamese patients following traumatic thumb amputation.

Cartilage tissue engineering for auricular reconstruction: in vitro evaluation of potential genotoxic and cytotoxic effects of scaffold materials.

Tissue engineering of autologous cartilage transplants is suggested as a new approach in reconstruction of external auricular deformities.

Cytotoxic and genotoxic effects of matrices for cartilage tissue engineering.

Customizing auricles with biodegradable polyurethane colonized with autologous chondrocytes as an approach for tissue engineering cartilage transplants has been suggested for the reconstruction of the external ear to repair auricular deformities.

Comparison of effective use of implanted vascular pedicles for skin flap prefabrication: an experimental study

Thin, large, well-vascularized, and axial-pattern flaps are often desired in the clinical practice of defect reconstruction to maximize esthetic and functional results.

Successful re-construction of a large tissue defect using a free pre-fabricated flap with purely implanted arterialised venous loop.

Flap pre-fabrication represents an interesting technique in tissue-defect reconstruction.

Optimization of platelet isolation and extraction of autogenous TGF-beta in cartilage tissue engineering.

Platelets are enriched with Transforming Growth Factor-beta (TGF-beta). However, information is limited concerning TGF-beta's effects at the molecular level.

Effectiveness of free gracilis muscle flaps in the treatment of chronic osteomyelitis with purulent fistulas at the distal third of the tibia in children.

Chronic purulent infection at the distal third of the tibia resulting from of a previous hematogenous osteomyelitis in children is a severe infection which is seldom reported in the literature and remains a difficult challenge for orthopaedic surgeons.

Complete middle forearm amputations after avulsion injuries--microsurgical replantation results in Vietnamese patients.

Replantation after complete avulsion amputations at the level of the middle forearm is rarely reported in the literature and remains one of the most difficult challenges for microsurgeons.

Management of facial necrotizing fasciitis.

Necrotizing fasciitis is a progressive, life-threatening, bacterial infection of the skin, the subcutaneous tissue and the underlying fascia, in most cases caused by ss-hemolytic group A streptococcus.

Neovascularization and free microsurgical transfer of in vitro cartilage-engineered constructs.

Cartilage tissue engineering shows to have tremendous potential for the reconstruction of three-dimensional cartilage defects. To ensure survival, shape, and function, in vitro cartilage-engineered constructs must be revascularized.

Loss of olfaction with aging: a frequent disorder receiving little attention

Loss of olfaction in old age is a frequent problem, which occurs at the same frequency as diabetes or severe sensorineural hearing loss.

Influence of silicone sheets on microvascular anastomosis.

The use of silicone products combined with free flap transfer is well established in reconstructive surgery. We determined the risk of thrombosis as a result of direct contact between the silicone sheet and the point of microanastomosis.

Case reports: thumb reconstruction using amputated fingers.

Reconstruction of an irreparably amputated thumb in multiple digit amputations using amputated fingers can considerably improve hand function and allows creation of a newly transplanted thumb with acceptable cosmetic and functional attributes.

Performance of conventional oral brush biopsies

This study evaluated the performance of oral brush biopsies using standard morphological analysis and haematoxylin and eosin (HE) staining for detecting oral squamous cell carcinomas and their respective precursor lesions.

In vitro and in vivo cartilage engineering using a combination of chondrocyte-seeded long-term stable fibrin gels and polycaprolactone-based polyurethane scaffolds.

The use of either a hydrogel or a solid polymeric scaffold alone is often associated with distinct drawbacks in many tissue engineering applications.

Therapy of auricular keloids: review of different treatment modalities and proposal for a therapeutic algorithm.

Keloids are abnormal wound reactions of connective tissue. Auricular keloids can develop as a result of, e.g., otoplasty, ear piercing, or skin trauma. A wide variety of therapeutic options exists, including surgery as primary treatment.

Mercuric dichloride induces DNA damage in human salivary gland tissue cells and lymphocytes.

Amalgam is still one of the most frequently used dental filling materials. However, the possible adverse effects especially that of the mercuric component have led to continued controversy.

Condylar resection alone versus alloplastic reconstruction. Comparison of long-term functional and cosmetic results

After condylar resection a decision on whether to proceed immediately to reconstruction has to be decided. In this paper, two patients who had undergone hemimandibulectomy including exarticulation, in one because of an expanded keratocystic odontogenic tumour and in the other because of oral squamous cell carcinoma, are presented.

Long-term stable fibrin gels for cartilage engineering.

It is essential that hydrogel scaffold systems maintain long-term shape stability and mechanical integrity for applications in cartilage tissue engineering.

Optimized auricular reconstruction with autologous cartilage. Experience from 120 cases

Auricular reconstruction with autologous cartilage has become well established in the last decade. By optimizing the technique, both the results and reliability have improved.

Effects of nicotine with special consideration given to tumorigenesis in the head and neck region

Tumorigenesis is based on initiation, promotion, and progression, whereas tobacco smoke is a decisive predisposing factor for squamous cell carcinomas of the upper aerodigestive tract.

Round window stimulation with an implantable hearing aid (Soundbridge) combined with autogenous reconstruction of the auricle - a new approach.

Congenital malformations of the auricle are often combined with atresia of the outer ear canal and malformations of the ossicles, representing aesthetic as well as functional deficits.

Central giant cell granuloma of the mandible. Definition and differential diagnosis

The synopsis of radiographic examination (uni- or multilocular radiolucency), histologic findings (giant cells throughout a benign fibroblastic matrix), blood chemistry analysis (normal serum parathyroid hormone) and clinical features provides the definitive diagnosis of giant cell granuloma, allowing the clearly defined surgical management of this lesion.

Cellulose-based scaffold materials for cartilage tissue engineering.

Non-woven cellulose II fabrics were used as scaffolds for in vitro cartilage tissue engineering. The scaffolds were activated in a saturated Ca(OH)(2) solution and subsequently coated with a calcium phosphate layer precipitated from a supersaturated physiological solution.

Does nicotine add to the carcinogenic strain of tobacco smoke?

It is accepted that nicotine in tobacco smoke causes addiction via nicotinic acetylcholine receptors in the central nervous system. For a long time, the tumorigenic potential of smoking was attributed to compounds other than nicotine.

Correction of ear malformations with autologous rib cartilage

Ear malformations are mainly isolated deformations but exist also in combination with various syndromes. A visible malformation in cases of microtia is a problem for the entire family.

Cytotoxic and genotoxic effects of resin monomers in human salivary ...

...gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay.

Dental injuries due to miniplate osteosynthesis. Classification, treatment management, complications, and prognosis

In spite of a monocortical design, miniplate osteosynthesis can injure dental roots directly as well as damage dental substance indirectly by interrupting the apical blood stream.

Prefabrication of large fasciocutaneous flaps using an isolated arterialised vein as implanted vascular pedicle.

lap prefabrication represents a new trend in microsurgical tissue transfer. Based on the concept of neovascularisation, in Chinchilla Bastard rabbits (n=40), an isolated venous pedicle dissected from the femoral and saphena magna vein was arterialised by end-to-end anastomosis to the femoral artery at the inguinal ligament.

Navigation-assisted construction of an external ear canal using an autogenous foreskin graft.

Classic microtia is combined with external ear canal atresia and middle ear malformation. In order to evaluate whether an operation to improve hearing ability and the use of computer-assisted surgery are indicated, preoperative high-resolution navigation CT is mandatory.

Proposed new method for angiographically quantifying neovascularization in prefabricated flaps.

Prefabricated flaps have many potential applications in plastic and reconstructive surgery. Despite numerous experimental investigations and clinical applications, a standard quantification procedure for analyzing neovascularization in prefabricated flaps has not yet been established in the literature.

Study of the neovascularisation of prefabrication of flaps using a silicone sheet and an isolated arterial pedicle: experimental study in rabbits.

Use of an isolated artery as an implanted pedicle in prefabricated flaps has rarely been reported either clinically or experimentally. In Chinchilla Bastard rabbits (n = 36), we dissected an isolated arterial pedicle from the femoral and saphenous artery, anastomosed it end-to-end to the femoral vein at the inguinal ligament and created an isolated arterial loop pedicle.

Neovascularization in prefabricated flaps using a tissue expander and an implanted arteriovenous pedicle.

Creating prefabricated flaps using tissue expanders in combination with the implantation of maximal blood flow vascular pedicles into suitable tissue areas represents a new tendency in the reconstruction of large skin defects.

Toxicological assessment of noxious inhalants.

In the past centuries mankind has been exposed to various forms of air pollution not only at his occupational but also in his social environment.

Flap prefabrication and prelamination with tissue-engineered cartilage.

In reconstructive surgery, the integration of tissue-engineered cartilage in a prefabricated free flap may make it possible to generate flaps combining a variety of tissue components, to meet the special requirements of particular defects.

Experimental investigation of neovascularisation in large prefabricated flaps after arteriovenous pedicle implantation

The principle of prefabricated flaps is based on the transformation of a formerly random-pattern vascularized flap, through implantation of a vascular pedicle, into a newly neovascularized axial flap, which can be transferred after a period of neovascularisation from the prepared donor site to the recipient site by using microvascular techniques.

Tissue-engineered cartilage in a prefabricated microvascularized flap

In reconstructive surgery, the integration of tissue-engineered cartilage in a prefabricated free flap may make it possible to generate flaps combining a variety of tissue components to meet the special requirements of a particular defect.

Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes

Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay.

Genotoxic effects of vanadium pentoxide on human peripheral lymphocytes

Genotoxic effects of vanadium pentoxide on human peripheral lymphocytes and mucosal cells of the upper aerodigestive tract.

Clinical aspects and strategy for biomaterial engineering of an auricle based on three-dimensional stereolithography.

At the present time, the partial and/or complete reconstruction of an auricle from autologous rib cartilage is one of most widely published techniques.

Malformations of the auricle and their correction

Owing to the stigma attached to auricular malformations, many patients request surgical correction. According to Weerda, such malformations can be classified into three grades of severity.

Mesenchymal stem cells--a new pathway for tissue engineering in reconstructive surgery

Mesenchymal stem cells (MSC) have the capacity to differentiate into chondrocytes with the synthesis of cartilage.

Dilated pneumosinus of the frontal sinus

Pneumosinus dilatans is a rare disorder of the frontal sinus most commonly found in 20- to 40-year-old males.

The characterisation of human respiratory epithelial cells

The characterisation of human respiratory epithelial cells cultured on resorbable scaffolds: first steps towards a tissue engineered tracheal replacement.

Local reconstruction of partial auricular defects

Partial auricular defects are often caused by resection of skin tumors. These patients are mainly older and often in reduced general condition. Therefore very expenditure surgical approaches seem to be dangerous.

Microtia: technique for external ear reconstruction with autologous rib cartilage.

Various methods for treatment of classic microtia are known. Beside a prosthesis, the most common way of auricle reconstruction is the use of autogenous rib cartilage;

Ear reconstruction supported by a stereolithographic model.

Ear reconstruction supported by a stereolithographic model.

Color comparison of donor sites of free flaps and the face

Microsurgical reconstructions of the face using free flaps from the body and the extremities often lead to imperfect aesthetic results.

Subcutaneous preservation of an amputated auricle. Morphological changes

Microsurgical replantation of an avulsed auricle remains a challenge in reconstructive surgery.

Highly malignant T-cell non-Hodgkin lymphoma (nasal type) of the hard palate

The monomorphic clinical aspect of destructive mid-face lesions is characterised by inflammation, induration and granulomatous transformation.

Autologous rib cartilage harvesting

Operative procedure and postoperative pain reduction.

Free microvascular rectus abdominis muscle ...

Free microvascular rectus abdominis muscle flap for soft tissue reconstruction of the lower leg and foot: results and donor site defect.

Donor-site morbidity of the segmental rectus abdominis muscle flap.

The donor-site morbidity of the segmental rectus abdominis muscle flap was evaluated in 20 patients with an average follow-up time of 47 months.

Results of surgical management of lunate malacia

Results of surgical management of lunate malacia.